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1

Oxidant-damage of viral proteins by NADPH-oxidase Nox4-induced radical production drives MHC class I antigen processing

Elke Krüger, Annika Warnatsch, Theresa Bergann, Frederic Ebstein, Peter-Michael Kloetzel

Journal:

Molecular Immunology

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

2

The effect of the interferon-γ-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context

Ulrike Kuckelkorn, Edite Antunes Ferreira, Ilse Drung, Ulrike Liewer, Peter-Michael Kloetzel, Matthias Theobald

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 168 KB

english, 2002

3

α-Keto-Aldehyd-Peptide: ein Leitmotiv für die Entwicklung reversibler Proteasominhibitoren

Dr. Melissa Ann Gräwert, Nerea Gallastegui, Martin Stein, Prof. Dr. Boris Schmidt, Prof. Dr. Peter-Michael Kloetzel, Prof. Dr. Robert Huber, Prof. Dr. Michael Groll

Journal:

Angewandte Chemie

Year:

2011

Language:

german

File:

PDF, 538 KB

german, 2011

4

Elucidation of the α-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition

Dr. Melissa Ann Gräwert, Nerea Gallastegui, Martin Stein, Prof. Dr. Boris Schmidt, Prof. Dr. Peter-Michael Kloetzel, Prof. Dr. Robert Huber, Prof. Dr. Michael Groll

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 525 KB

english, 2011

5

HLA–B27–restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis

Pamir Atagunduz, Heiner Appel, Wolfgang Kuon, Peihua Wu, Andreas Thiel, Peter-Michael Kloetzel, Joachim Sieper

Journal:

Arthritis & Rheumatism

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

6

Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28

Michael Brychcy, Ulrike Kuckelkorn, Gert Hausdorf, Karl Egerer, Peter-M. Kloetzel, Gerd-R. Burmester, Eugen Feist

Journal:

Arthritis & Rheumatism

Year:

2006

Language:

english

File:

PDF, 597 KB

english, 2006

7

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo

Natascha de Graaf, Mary J. G. van Helden, Kathrin Textoris-Taube, Tomoki Chiba, David J. Topham, Peter-Michael Kloetzel, Dietmar M. W. Zaiss, Alice J. A. M. Sijts

Journal:

European Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 320 KB

english, 2011

8

Proteasome and peptidase function in MHC-class-I-mediated antigen presentation

Peter-Michael Kloetzel, Ferry Ossendorp

Journal:

Current Opinion in Immunology

Year:

2004

Language:

english

File:

PDF, 482 KB

english, 2004

9

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28

Ralf Stohwasser, Ulrike Salzmann, Jan Giesebrecht, Peter-Michael Kloetzel, Hermann-Georg Holzhütter

Journal:

Year:

2000

Language:

english

File:

PDF, 805 KB

english, 2000

10

The 70 kD heat shock protein (hsp 70) in soil invertebrates: A possible tool for monitoring environmental toxicants

Heinz-Rüdiger Köhler, Rita Triebskorn, Walter Stöcker, Peter-Michael Kloetzel, Gerd Alberti

Journal:

Archives of Environmental Contamination and Toxicology

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

11

Reciprocal Effects of α-Synuclein Overexpression and Proteasome Inhibition in Neuronal Cells and Tissue

Melanie Dyllick-Brenzinger, Cheryl A. D’Souza, Burkhardt Dahlmann, Peter-Michael Kloetzel, Anurag Tandon

Journal:

Neurotoxicity Research

Year:

2010

Language:

english

File:

PDF, 767 KB

english, 2010

12

Consequences of COP9 signalosome and 26S proteasome interaction

Xiaohua Huang, Bettina K. J. Hetfeld, Ulrike Seifert, Thilo Kähne, Peter-Michael Kloetzel, Michael Naumann, Dawadschargal Bech-Otschir, Wolfgang Dubiel

Journal:

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

13

10.1038/12043

Braun, Beate C., Glickman, Michael, Kraft, Regine, Dahlmann, Burkhardt, Kloetzel, Peter-M., Finley, Daniel, Schmidt, Marion

Journal:

Nature Cell Biology

Year:

1999

Language:

english

File:

PDF, 582 KB

english, 1999

14

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome

Bech-Otschir, Dawadschargal, Helfrich, Annett, Enenkel, Cordula, Consiglieri, Gesa, Seeger, Michael, Holzhütter, Hermann-Georg, Dahlmann, Burkhardt, Kloetzel, Peter-Michael

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 525 KB

english, 2009

15

The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum

Fricke, Benjamin, Heink, Sylvia, Steffen, Janos, Kloetzel, Peter-Michael, Krüger, Elke

Journal:

Year:

2007

Language:

english

File:

PDF, 282 KB

english, 2007

16

GFP-labelling of 26S proteasomes in living yeast: insight into proteasomal functions at the nuclear envelope/rough ER

Cordula Enenkel, Andrea Lehmann, Peter-Michael Kloetzel

Journal:

Molecular Biology Reports

Year:

1999

Language:

english

File:

PDF, 46 KB

english, 1999

17

Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope–ER network in yeast

Enenkel, Cordula, Lehmann, Andrea, Kloetzel, Peter-Michael

Journal:

The EMBO Journal

Year:

1998

Language:

english

File:

PDF, 368 KB

english, 1998

18

The FAT10- and ubiquitin-dependent degradation machineries exhibit common and distinct requirements for MHC class I antigen presentation

Ebstein, Frédéric, Lehmann, Andrea, Kloetzel, Peter-Michael

Journal:

Cellular and Molecular Life Sciences

Year:

2012

Language:

english

File:

PDF, 525 KB

english, 2012

19

Emerging roles of immunoproteasomes beyond MHC class I antigen processing

Ebstein, Frédéric, Kloetzel, Peter-Michael, Krüger, Elke, Seifert, Ulrike

Journal:

Cellular and Molecular Life Sciences

Year:

2012

Language:

english

File:

PDF, 377 KB

english, 2012

20

The Zinc Finger of the CSN-Associated Deubiquitinating Enzyme USP15 Is Essential to Rescue the E3 Ligase Rbx1

Bettina K.J. Hetfeld, Annett Helfrich, Barbara Kapelari, Hartmut Scheel, Kay Hofmann, Adi Guterman, Michael Glickman, Rüdiger Schade, Peter-Michael Kloetzel, Wolfgang Dubiel

Journal:

Current Biology

Year:

2005

Language:

english

File:

PDF, 264 KB

english, 2005

21

Ubiquitin-receptor CXCR4 promotes cross presentation through facilitated uptake of poly-ubiquitylated antigens

Frédéric Ebstein, Andrea Lehmann, Peter-Michael Kloetzel

Journal:

Molecular Immunology

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

22

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma

Ulrike Heider, Ivana von Metzler, Martin Kaiser, Marleen Rosche, Jan Sterz, Susanne Rötzer, Jessica Rademacher, Christian Jakob, Claudia Fleissner, Ulrike Kuckelkorn, Peter-Michael Kloetzel, Orhan Sez

Journal:

European Journal of Haematology

Year:

2008

Language:

english

File:

PDF, 236 KB

english, 2008

23

Inhibition of the Ubiquitin-Proteasome Pathway Induces Differential Heat-Shock Protein Response in Cardiomyocytes and Renders Early Cardiac Protection

Karl Stangl, Christoph Günther, Thomas Frank, Mario Lorenz, Silke Meiners, Thorsten Röpke, Lars Stelter, Minoo Moobed, Gert Baumann, Peter-Michael Kloetzel, Verena Stangl

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

24

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome

Hermann-Georg Holzhütter, Cornelius Frömmel, Peter-Michael Kloetzel

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 359 KB

english, 1999

25

20 S proteasomes are imported as precursor complexes into the nucleus of yeast

Andrea Lehmann, Katharina Janek, Beate Braun, Peter-Michael Kloetzel, Cordula Enenkel

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 1.18 MB

english, 2002

26

20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2Ld epitope from a recombinant protein

Antje Voigt, Ulrike Salzmann, Ulrike Seifert, Margitta Dathe, Andrea Soza, Peter-Michael Kloetzel, Ulrike Kuckelkorn

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 243 KB

english, 2007

27

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

Frédéric Ebstein, Nicole Lange, Sabrina Urban, Ulrike Seifert, Elke Krüger, Peter-Michael Kloetzel

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2009

Language:

english

File:

PDF, 1.06 MB

english, 2009

28

The Ubiquitin-domain Protein HERP forms a Complex with Components of the Endoplasmic Reticulum Associated Degradation Pathway

Andrea Schulze, Sybille Standera, Elke Buerger, Marjolein Kikkert, Sjaak van Voorden, Emmanuel Wiertz, Frits Koning, Peter-Michael Kloetzel, Michael Seeger

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 329 KB

english, 2005

29

The RTP Site Shared by the HIV-1 Tat Protein and the 11 S Regulator Subunit α is Crucial for their Effects on Proteasome Function Including Antigen Processing

Xiaohua Huang, Ulrike Seifert, Ulrike Salzmann, Peter Henklein, Robert Preissner, Wolfgang Henke, Alice J. Sijts, Peter-Michael Kloetzel, Wolfgang Dubiel

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 1.49 MB

english, 2002

30

A Comprehensive View on Proteasomal Sequences: Implications for the Evolution of the Proteasome

Christoph Gille, Andrean Goede, Cord Schlöetelburg, Robert Preißner, Peter-Michael Kloetzel, Ulf B. Göbel, Cornelius Frömmel

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 4.03 MB

english, 2003

31

20S proteasome biogenesis

Elke Krüger, Peter-Michael Kloetzel, Cordula Enenkel

Journal:

Year:

2001

Language:

english

File:

PDF, 245 KB

english, 2001

32

Differential Interferon Responses Enhance Viral Epitope Generation by Myocardial Immunoproteasomes in Murine Enterovirus Myocarditis

Sandra Jäkel, Ulrike Kuckelkorn, Gudrun Szalay, Michael Plötz, Kathrin Textoris-Taube, Elisa Opitz, Karin Klingel, Stefan Stevanovic, Reinhard Kandolf, Katja Kotsch, Karl Stangl, Peter M. Kloetzel, An

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 849 KB

english, 2009

33

The 20S Proteasome Splicing Activity Discovered by SpliceMet

Liepe, Juliane, Mishto, Michele, Textoris-Taube, Kathrin, Janek, Katharina, Keller, Christin, Henklein, Petra, Kloetzel, Peter Michael, Zaikin, Alexey, De Boer, Rob J.

Journal:

PLoS Computational Biology

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

34

A Kinetic Model of Vertebrate 20S Proteasome Accounting for the Generation of Major Proteolytic Fragments from Oligomeric Peptide Substrates

Holzhütter, Hermann-Georg, Kloetzel, Peter-Michael

Journal:

Biophysical Journal

Year:

2000

Language:

english

File:

PDF, 212 KB

english, 2000

35

Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities

Gohlke, Sabrina, Mishto, Michele, Textoris-Taube, Kathrin, Keller, Christin, Giannini, Carolin, Vasuri, Francesco, Capizzi, Elisa, DâErrico-Grigioni, Antonia, Kloetzel, Peter-Michael, Dahlmann, Burk

Journal:

Year:

2014

Language:

english

File:

PDF, 876 KB

english, 2014

36

α-Keto Phenylamides as P1′-Extended Proteasome Inhibitors

Voss, Constantin, Scholz, Christoph, Knorr, Sabine, Beck, Philipp, Stein, Martin L., Zall, Andrea, Kuckelkorn, Ulrike, Kloetzel, Peter-Michael, Groll, Michael, Hamacher, Kay, Schmidt, Boris

Journal:

Year:

2014

Language:

english

File:

PDF, 1000 KB

english, 2014

37

T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes

Bochmann, Isabel, Ebstein, Frédéric, Lehmann, Andrea, Wohlschlaeger, Jeremias, Sixt, Stephan Urs, Kloetzel, Peter-Michael, Dahlmann, Burkhardt

Journal:

Journal of Cellular and Molecular Medicine

Year:

2014

Language:

english

File:

PDF, 397 KB

english, 2014

38

Herp Regulates Hrd1-mediated Ubiquitylation in a Ubiquitin-like Domain-dependent Manner

Kny, Melanie, Standera, Sybille, Hartmann-Petersen, Rasmus, Kloetzel, Peter-Michael, Seeger, Michael

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

39

Driving Forces of Proteasome-catalyzed Peptide Splicing in Yeast and Humans

Mishto, M., Goede, A., Taube, K. T., Keller, C., Janek, K., Henklein, P., Niewienda, A., Kloss, A., Gohlke, S., Dahlmann, B., Enenkel, C., Michael Kloetzel, P.

Journal:

Molecular & Cellular Proteomics

Year:

2012

Language:

english

File:

PDF, 1.69 MB

english, 2012

40

Modelling Proteasome and Proteasome Regulator Activities

Liepe, Juliane, Holzhütter, Herman-Georg, Kloetzel, Peter, Stumpf, Michael, Mishto, Michele

Journal:

Year:

2014

Language:

english

File:

PDF, 330 KB

english, 2014

41

Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity

Moncsek, Anja, Gruner, Melanie, Meyer, Hannes, Lehmann, Andrea, Kloetzel, Peter-Michael, Stohwasser, Ralf

Journal:

Year:

2015

Language:

english

File:

PDF, 2.03 MB

english, 2015

42

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome’s β5 Catalytic Subunit

Bensinger, Dennis, Neumann, Theresa, Scholz, Christoph, Voss, Constantin, Knorr, Sabine, Kuckelkorn, Ulrike, Hamacher, Kay, Kloetzel, Peter-Michael, Schmidt, Boris

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

43

Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination

Golnik, Richard, Lehmann, Andrea, Kloetzel, Peter-Michael, Ebstein, Frédéric

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.69 MB

english, 2016

44

Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

Ebstein, Frédéric, Keller, Martin, Paschen, Annette, Walden, Peter, Seeger, Michael, Bürger, Elke, Krüger, Elke, Schadendorf, Dirk, Kloetzel, Peter-M., Seifert, Ulrike

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

45

ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T cell therapy in mice

Schmidt, Karin, Keller, Christin, Kühl, Anja A, Textor, Ana, Seifert, Ulrike, Blankenstein, Thomas, Willimsky, Gerald, Kloetzel, Peter-Michael

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 1.25 MB

english, 2018

46

Use of Rifapentine and Isoniazid Directly Observed Therapy for the Treatment of Latent Tuberculosis Infection in a Military Clinic

Jinbo, Janelle, Lustik, Michael, West, Gordon F., Kloetzel, Megan

Journal:

Military Medicine

Year:

2017

Language:

english

File:

PDF, 459 KB

english, 2017

47

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia

Kirschner, Felicia, Reppe, Katrin, Andresen, Nadine, Witzenrath, Martin, Ebstein, Frédéric, Kloetzel, Peter-Michael, Edelmann, Mariola J

Journal:

Year:

2016

Language:

english

File:

PDF, 2.48 MB

english, 2016

48

Adult human liver contains intermediate-type proteasomes with different enzymatic properties

Gohlke, Sabrina, Kloβ, Alexander, Tsokos, Michael, Textoris-Taube, Kathrin, Keller, Christin, Kloetzel, Peter-Michael, Dahlmann, Burkhardt

Journal:

Annals of Hepatology

Year:

2014

Language:

english

File:

PDF, 302 KB

english, 2014

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